Can we trust machines to handle tasks independently and improve autonomously? While there’s hope for the future, a comparison of human and machine capabilities reveals the human brain’s significant edge. With 86 billion neurons and 150 trillion synapses, it surpasses the best machine models by two orders of magnitude. Despite advancements, we’re at the level of a house mouse in deep learning, suggesting a continued symbiotic relationship. Excitingly, FDA AI device approvals, especially in radiology, indicate progress. In MS applications, traditional and subtler approaches emerge, addressing MR acquisition, diagnosis, and prognosis. Notably, four data usage approaches stand out, offering promising avenues for future exploration.